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Certain miRNAs in gastric juice can be used as biomarkers for the detection of gastric cancer
MicroRNAs (miRNAs) play crucial roles during
carcinogenesis, but whether miRNAs in gastric juice, which is specific for
gastric tissues, can be used as biomarkers of gastric cancer is largely
unclear. Patients with gastric cancer had significantly different level of
gastric juice miR-21 and miR -106a compared with patients with benign
gastric diseases. The areas under ROC curves were up to 0.969 and 0.871 for
miR-21 and miR -106a , respectively. Certain miRNAs including miR-21 and miR -106a in
gastric juice can be used as biomarkers for the detecting of gastric cancer
with a satisfactory specificity and sensitivity.
Bibliographic Reference:
Junming Guo Zhejiang
Provincial Key Laboratory of Pathophysiology, Department of Biochemistry
and Molecular Biology, Ningbo University School of Medicine, Ningbo, China
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