Strategies for the management of triple negative breast cancer

Triple negative breast cancer (TNBC) is a minor subtype and has distinctive aspect of clinical behavior. TNBC often shows rapid and expanding growth pattern, unlike luminal type. Chemotherapy is the only method as systemic therapy and shows remarkable effect with relatively high probability, to the contrary, some of TNBCs show overt progression in a short period during chemotherapy and develop early recurrence with short survival. Various molecular targeting therapies are developing, but do not reach our daily practice. So we tried to explore effective ways of treatment for TNBC from both previous reports and our experiences in the literature. We need to consider effective treatment strategy for TNBC, including local therapy as well as systemic therapy with special care.

Bibliographic Reference:

Yagata H et al.: "Current strategy for triple-negative breast cancer: appropriate combination of surgery, radiation, and chemotherapy", Breast Cancer. 2011 Feb 3. [Epub ahead of print]

Hiroshi Yagata