Editor-in-Chief: Gian Paolo Andreoletti, MD

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Literature Selection

• Hubbard RA et al.: "Cumulative probability of false-positive recall or biopsy recommendation after 10 years of screening mammography: a cohort study", Ann Intern Med. 2011 Oct 18;155(8):481-92
• Takeshita T et al.: "Clinical Implications of Occult Metastases and Isolated Tumor Cells in Sentinel and Non-Sentinel Lymph Nodes in Early Breast Cancer Patients: Serial Step Section Analysis with Long-Term Follow-Up", Ann Surg Oncol. 2011 Oct 12. [Epub ahead of print]
• Han Y et al.: "Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer", Breast Cancer Res Treat. 2011 Oct 5. [Epub ahead of print]
• Arun B et al.: "Response to Neoadjuvant Systemic Therapy for Breast Cancer in BRCA Mutation Carriers and Noncarriers: A Single-Institution Experience", J Clin Oncol. 2011 Oct 1;29(28):3739-46
• Mohammadianpanah M et al.: "The efficacy and safety of neoadjuvant chemotherapy +/- letrozole in postmenopausal women with locally advanced breast cancer: a randomized phase III clinical trial", Breast Cancer Res Treat. 2011 Oct 16. [Epub ahead of print]
• Stearns V et al.: "Preclinical and clinical evaluation of intraductally administered agents in early breast cancer", Sci Transl Med. 2011 Oct 26;3(106):106ra108
• Regan MM et al.: "Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up", Lancet Oncol. 2011 Oct 20. [Epub ahead of print]
• Slamon D et al.: "Adjuvant trastuzumab in HER2-positive breast cancer", N Engl J Med. 2011 Oct 6;365(14):1273-83
• Brufsky AM et al.: "Final 5-year results of Z-FAST trial: Adjuvant Zoledronic Acid Maintains Bone Mass in Postmenopausal Breast Cancer Patients Receiving Letrozole", Cancer. 2011 Oct 10  [Epub ahead of print]
• Adkins FC et al.: "Triple-negative breast cancer is not a contraindication for breast conservation", Ann Surg Oncol. 2011 Oct;18(11):3164-73
• Early Breast Cancer Trialists' Collaborative Group (EBCTCG): "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials", Lancet. 2011 Oct 19. [Epub ahead of print]
• Miao H et al.: "Incidence and Outcome of Male Breast Cancer: An International Population-Based Study", J Clin Oncol. 2011 Oct 3. [Epub ahead of print]

Comment

• "Patients with small, node-negative HER2-positive breast carcinoma may benefit from trastuzumab therapy" - Ana Kiess, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
   
  ""Our study shows that women with small, node-negative HER2-positive breast cancer may benefit from trastuzumab therapy.                                                                                                                                                    These women actually have a significant risk of local recurrence in the breast after breast conservation therapy (~10%), but trastuzumab may reduce their risk to about 1%"
  (Comment on:  Kiess AP et al.: "Adjuvant trastuzumab reduces locoregional recurrence in women who receive breast-conservation therapy for lymph node-negative, human epidermal growth factor receptor 2-positive breast cancer", Cancer. 2011 Sep 1. doi: 10.1002/cncr.26484. [Epub ahead of print])

Discussion

• Welch HG et al.: "Likelihood That a Woman With Screen-Detected Breast Cancer Has Had Her "Life Saved" by That Screening", Arch Intern Med. Published online October 24, 2011,  doi:10.1001/archinternmed.2011.476
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Healthcare Companies News

• Oncotype DX Newsletter - Genomic Health

Calendar of Events

• 1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon, Portugal
• IX Madrid Breast Cancer Conference, November 16 - 17, 2011, Madrid, Spain
• AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference, November 28 - December 2, 2011, Cairo, Egypt
• The 2011 CTRC-AACR San Antonio Breast Cancer Symposium,  December 6-10, 2011, San Antonio, TX
• The World Cancer Immunotherapy Conference, January 25-26, 2012, San Diego, CA

Fragments of History

• William S Halsted  (New York, 1852-1922),  "The Results of Operations for the Cure of Cancer of the Breast  Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894, Ann Surg. 1894 November; 20(5): 497–555:  “Now we can state positively that cancer of the breast is a curable disease if operated upon properly and in time. I cannot emphasize too strongly the fact that internal metastases occur very early in cancer of the breast, and this is an additional reason for not losing a day in discussing the propriety of an operation"  

Literature Selection

• Gillgren P et al.: "2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial", Lancet. 2011 Oct 21. [Epub ahead of print]
• Chaturvedi AK et al.: "Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States", J Clin Oncol. 2011 Oct 3. [Epub ahead of print]
• Palefsky JM et al.: "HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia", N Engl J Med. 2011 Oct 27;365(17):1576-1585
• Hvid-Jensen F et al.: "Incidence of Adenocarcinoma among Patients with Barrett's Esophagus", N Engl J Med. 2011 Oct 13;365(15):1375-83
• Herbrik M et al.: "Diagnostic Accuracy of Virtual 18F-FDG PET/CT Bronchoscopy for the Detection of Lymph Node Metastases in Non-Small Cell Lung Cancer Patients", J Nucl Med. 2011 Oct;52(10):1520-5
• Oken MM et al.: "Screening by Chest Radiograph and Lung Cancer Mortality: The Prostate, Lung, Colorectal, and Ovarian (PLCO) Randomized Trial", JAMA. 2011 Oct 26. [Epub ahead of print]
• Quoix E et al.: "Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial", Lancet Oncol. 2011 Oct 21. [Epub ahead of print]
• Ruge M et al.: "Stereotactic Brachytherapy With Iodine-125 Seeds for the Treatment of Inoperable Low-Grade Gliomas in Children: Long-Term Outcome", J Clin Oncol. 2011 Oct 3. [Epub ahead of print]
• Yang D et al.: "Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer", JAMA. 2011 Oct 12;306(14):1557-65
• Klein EA et al.: "Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)", JAMA. 2011 Oct 12;306(14):1549-56
• Miyatake H et al.: "Effect of Previous Interferon Treatment on Outcome After Curative Treatment for Hepatitis C Virus-Related Hepatocellular Carcinoma", Dig Dis Sci. 2011 Oct 12. [Epub ahead of print]
• Garcia-Donas J et al.: "Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study", Lancet Oncol. 2011 Oct 17. [Epub ahead of print]

Discussion

• "Screening for Prostate Cancer - A Review of the Evidence for the U.S. Preventive Services Task Force"
  • - "Prostate cancer screening guidelines called into question", Dana-Farber Cancer Institute 
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