Editor-in-Chief: Gian Paolo Andreoletti, MD

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Literature Selection

• Verma S et al.: "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer", N Engl J Med. 2012 Oct 1. [Epub ahead of print]
• Shim JS et al.: "Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir", J Natl Cancer Inst. 2012 Oct 5. [Epub ahead of print]
• Esposito A et al.: "Are there benefits in routine clinical practice of continuing trastuzumab after progression for metastatic breast cancer patients?", Anticancer Drugs. 2012 Nov;23(10):1089-98
• Hannouf MB et al.: "Cost-effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in women with early-stage estrogen- or progesterone-receptor-positive, axillary lymph-node negative breast cancer, BMC Cancer. 2012 Oct 2;12(1):447. [Epub ahead of print]
• Vataire AL et al.: "Cost-effectiveness of a chemotherapy predictive test", Bull Cancer. 2012 Oct 5. [Epub ahead of print]
• Carayol M et al.: "Psychological effect of exercise in women with breast cancer receiving adjuvant therapy: what is the optimal dose needed?", Ann Oncol. 2012 Oct 5. [Epub ahead of print]
• Saadatmand SS et al.: "Breast density as indicator for the use of mammography or MRI to screen women with familial risk for breast cancer (FaMRIsc): a multicentre randomized controlled trial", BMC Cancer. 2012 Oct 2;12(1):440. [Epub ahead of print]
• Bluekens AM et al.: "Comparison of Digital Screening Mammography and Screen-Film Mammography in the Early Detection of Clinically Relevant Cancers: A Multicenter Study", Radiology. 2012 Oct 2. [Epub ahead of print]
• Zhao Y et al.: "High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers", Proc Natl Acad Sci U S A. 2012 Oct 22. [Epub ahead of print]
• Berghoff AS et al.: "Brain-only metastatic breast cancer is a distinct clinical entity characterised by favourable median overall survival time and a high rate of long-term survivors", Br J Cancer. 2012 Oct 9 [Epub ahead of print]
• Eirò N et al.: "Prediction of metastatic breast cancer in non-sentinel lymph nodes based on metalloprotease-1 expression by the sentinel lymph node", Eur J Cancer. 2012 Oct 11[Epub ahead of print]
• Medhavan D et al.: "Circulating miRNAs as Surrogate Markers for Circulating Tumor Cells and Prognostic Markers in Metastatic Breast Cancer", Clin Cancer Res. 2012 Oct 18. [Epub ahead of print]

Comment

• "Preoperative needle biopsy improves the quality of surgery in women with breast cancer",Ted A. James, Department of Surgery, University of Vermont College of Medicine, Burlington, VT, USA
   
  "Our study demonstrates that obtaining a pre-operative diagnosis of cancer significantly improves surgical outcomes with respect to margin control and the total number of operations required to treat a patient with breast cancer. This translates into improved quality of care for the patient and a reduction in health care costs associated with secondary procedures. As much as it is possible, attempts should be made to perform a needle biopsy to confirm the presence of breast cancer prior to the patient going to the operating room. Further study is required to better understand barriers to the use of pre-operative needle biopsies, and efforts made to expand its use in the diagnosis breast cancer ".
  (Commentary on:  James TA et al.: "Preoperative needle biopsy improves the quality of breast cancer surgery", J Am Coll Surg. 2012 Oct;215(4):562-8)

Discussion

  "Regional nodal irradiation after a positive sentinel lymph node is a reasonable alternative to axillary dissection in early breast cancer" - Share your opinion on  LinkedIn®

Questions and Answers 

• Breast Cancer Medical Therapy Workshop Summary - with George Somlo, City of Hope Comprehensive Cancer Center, Duarte, CA, USA  
• Breast Cancer Radiotherapy Workshop Summary - with Simona Shaitelman, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA  
• Breast Cancer Genomic Profiling Workshop Summary - with Joseph Sparano,  Albert Einstein College of Medicine, New York, NY, USA

Fragments of History

• 1932 - Geoffrey Langdon Keynes in London uses radium as the sole treatment of operable cases of breast cancer (Keynes GL.:  "The radium treatment of carcinoma of the breast",  Brit J Surg 1942;19:415–80)

Calendar of Events

• Breast Cancer in Young Women Conference,  November 8-10,  2012,  Dublin, Ireland  
• IBUS - International Breast Ultrasound Course,  November 13-15, 2012, Tel Aviv, Israel
• 8th Meet the Professor. Advanced International Breast Cancer Conference (AIBCC), November 15-17, 2012, Padova , Italy - with the Patronage of Senology.org
• 2012 CTRC-AACR San Antonio Breast Cancer Symposium, December 4-8, 2012, San Antonio, TX, USA
• 2nd San Marino Breast Forum, December 1, 2012, San Marino, San Marino, SRM

Literature Selection

• Chaichana KL et al.: "Multiple resections for patients with glioblastoma: prolonging survival", J Neurosurg. 2012 Oct 19. [Epub ahead of print]
• Dillon KE et al.: "Pretreatment antimüllerian hormone levels determine rate of posttherapy ovarian reserve recovery: acute changes in ovarian reserve during and after chemotherapy", Fertil Steril. 2012 Oct 18 [Epub ahead of print]
• Cheng AS et al.: "Helicobacter pylori Causes Epigenetic Dysregulation of FOXD3 to Promote Gastric Carcinogenesis", Gastroenterology. 2012 Oct 8[Epub ahead of print]
• Liao X et al.: "Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival", N Engl J Med. 2012 Oct 25;367(17):1596-606
• Pizzichetta MA et al.: "Negative pigment network: An additional dermoscopic feature for the diagnosis of melanoma", J Am Acad Dermatol. 2012 Oct 9 [Epub ahead of print]
• Olmos D et al.: "Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study", Lancet Oncol. 2012 Oct 8 [Epub ahead of print]
• Parent ME et al.: "Night Work and the Risk of Cancer Among Men", Am J Epidemiol. 2012 Oct 3. [Epub ahead of print]
• Bolla M et al.: "Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911)", Lancet. 2012 Oct 18 [Epub ahead of print]

Questions and Answers 

• Kidney Cancer Workshop Summary 1 and Summary 2 - with Nicholas Vogelzang, Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA, and with Scott Tykodi, University of Washington, Seattle, WA, USA
• Prostate Cancer Workshop Summary 1 and Summary 2 - with Daniel Petrylak, Yale Cancer Center and Smilow Cancer Hospital, Yale, New Haven, USA, and with Cy Stein, City of Hope, Duarte, CA, USA 
• Leukemia Workshop Summary - with Jonathan Kolitz, North Shore University Hospital/LIJ Medical Center, New York, NY, USA
• Myeloma Workshop Summary - with Craig Hofmeister,  Ohio State University College of Medicine, Columbus, OH, USA 
• Melanoma Workshop Summary - with Richard Joseph, Mayo Clinic, Florida, USA

Literature Selection

• Schierbeck LL et al.: "Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial", BMJ. 2012 Oct 9;345:e6409